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Health Diaries > The Lung Cancer Blog
November 17, 2008
Study Sheds Light on Why Only Some Smokers Get Lung Cancer
New research is being done to find out why only some smokers end up getting lung cancer and one reason may be something called methylation, an event regulating gene expression that changes as people age.
"Alteration to DNA methylation might potentially explain why some former smokers sustain additional genetic damage resulting in lung cancer," Vucic said. "As methylation is a reversible DNA modification, this knowledge could prompt the development and application of chemopreventive agents and unique therapeutic strategies that target DNA methylation in these patients."
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Does anyone know whether the DDT fog that was sprayed years ago against mosquitoes would have an effect on causing a change in the body that would make one more susceptible to getting lung cancer???
These points to an interesting article in findrxonline where they talk about this subject it is necessary to inform the community.
It is ultimately the patient's responsibility to use narcotics responsibly.
A few years ago, narcotics were only prescribed after surgery, severe trauma, or for terminal cancer because of a concern over the possibility of addiction. Recently, they have been cautiously prescribed to treat moderate to severe non-malignant chronic pain in conjunction with other modalities such as physical therapy, cortisone and trigger point injections, muscle stretching, meditation, or aqua therapy. Unfortunately, the upsurge of narcotics as medical treatment also increased associated cases of abuse and addiction.
Derived from either opium (made from poppy plants) or similar synthetic compounds, narcotics not only block pain signals and reduce pain, but they affect other neurotransmitters, which can cause addiction. When taken for short periods, only minor side effects such as nausea, constipation, sedation and unclear thinking are noted.
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It is my hypothesis that low DHEA may trigger cancer (Annals of Internal Medicine 2005; 142: 471-472). I suggest the reason cancer occurs more often in the elderly is because DHEA declines rapidly in the elderly. However, just like smoking does not cause cancer in all smokers, cancer does not occur in all old people.
I suggest that low DHEA actually allows certain cells to proliferate by counteracting the effects differentiation caused by high DHEA. Some of these cells may contain genes that have not been inhibited by differentiation, that is, oncogenes. Therefore, low DHEA may trigger cancer in some old people and some smokers, depending upon the presence of oncogenes.
It is my hypothesis that all drugs of addiction produce their effects by first stimulation of the brain by the drug which then triggers a rebound production of DHEA. Ultimately these drugs reduce the life span production of DHEA, which, I suggest, is necessary for health and life span. Cigarette smoking has been connected with DHEA production. I suggest the "reason" for smoking is, in fact, the production of DHEA which increases energy and alertness.
Smoking may advance the aging process, that is, smoking may advance the time when DHEA levels reach the levels of old age. If such a smoker is carrying onocogenes, they may develop cancer, if not, then they may not develop cancer.